ML 604086( ML604086 )

Catalog No. M16173 CAS No. 850330-18-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ML 604086
Note

Research use only, not for human use.
Brief Description

ML 604086 (ML604086) is a potent, selective CCR8 inhibitor that inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations with IC50 of 1.3?uM and 1.0?uM respectively in cellular assays.
Description

ML 604086 (ML604086) is a potent, selective CCR8 inhibitor that inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations with IC50 of 1.3?uM and 1.0?uM respectively in cellular assays; displays high selectvity against a panel of 40 GPCRs, only moderately inhibits 5HT1a (30% at 10?uM).
In Vitro

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In Vivo

Animal Model:3.0-5.0 kg male and female adult Macaca fascicularis (primate model of asthma)Dosage:1.038 mg/kg Administration:Intravenous infusion Result:Did not effected the Changes in airway resistance and compliance induced by allergen provocation and increasing concentrations of methacholine.
Synonyms

ML604086
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

——
Indication

——

CAS Number

850330-18-6
Formula Weight

508.637
Molecular Formula

C27H32N4O4S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 120 mg/mL (235.93 mM)
SMILES

O=C(NC1=C2C=CC=CC2=C(S(=O)(N[C@H]3[C@H](C)CN(C([C@@H](N)C)=O)CC3)=O)C=C1)C4=CC=CC=C4C
Chemical Name

N-[4-[[[(3R,4R)-1-[(2S)-2-Amino-1-oxopropyl]-3-methyl-4-piperidinyl]amino]sulfonyl]-1-naphthalenyl]-2-methylbenzamide

1. Jenkins TJ, et al. J Med Chem. 2007 Feb 8;50(3):566-84. 2. Wang L, et al. Thorax. 2013 Jun;68(6):506-12.

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